There is an increased interest in plasmid DNA as therapeutics. This is evident in the number\nof ongoing clinical trials involving the use of plasmid DNA. In order to be an effective therapeutic,\nhigh yield and high level of supercoiling are required. From the bioprocessing point of view, the\nsupercoiling level potentially has an impact on the ease of downstream processing. We approached\nmeeting these requirements through plasmid engineering............................
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